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Article

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

6 Feb 2019

Abstract excerpt

OBJECTIVE: To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS). METHODS: Linkage disequilibrium score regression and Mendelian randomization were applied in a large-scale, data-driven manner to explore genetic correlations and causal relationships between >700 phenotypic traits and ALS. Exposures consisted of publicly available genome-wide association studies (GWASes)...

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PMID: 30723964
DOI: 10.1002/ana.25431

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