Article
Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.
Cancer immunology, immunotherapy : CII - 1 Jan 2022
Butler Savannah E, Brog Rachel A, Chang Cheryl H, Sentman Charles L, Huang Yina H, Ackerman Margaret E
Abstract excerpt
B7H6, a stress-induced ligand which binds to the NK cell receptor NKp30, has recently emerged as a promising candidate for immunotherapy due to its tumor-specific expression on a broad array of human tumors. NKp30 can function as a chimeric antigen receptor (CAR) extracellular domain but exhibits weak binding with a fast on and off rate to B7H6 compared to the TZ47 anti-B7H6 single-chain variable fragment (scFv)....
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