Article

FcɛR1γ-based Activating Chimeric Antigen Receptors enhanced Natural Killer cell function against HLA-E <sup>+</sup> cells

2025-06-20

Abstract excerpt

FcɛR1γ is a transmembrane adaptor protein regulating NKp30, NKp46, and CD16 expression and function in human NK cells. HLA-E expression by cancer cells suppresses NK cell function through interaction with NKG2A. Here, we engineered human NK cells to express a modified FcɛR1γ with a 4-1BB co-stimulatory motif. FcɛR1γ 41BB expression led to upregulation of NKp30, NKp46, and CD16 expression and enhanced NKp30 and CD...

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Literature Corpus work: 644fef03-53b9-5f8c-8a55-4a058a4d92b6
DOI: 10.1101/2025.06.16.659984

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