Article
Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2020
Sharma Preeti, Marada Venkata V V R, Cai Qi, Kizerwetter Monika, He Yanran, Wolf Steven P, Schreiber Karin, Clausen Henrik, Schreiber Hans, Kranz David M
Abstract excerpt
The potency of adoptive T cell therapies targeting the cell surface antigen CD19 has been demonstrated in hematopoietic cancers. It has been difficult to identify appropriate targets in nonhematopoietic tumors, but one class of antigens that have shown promise is aberrant O-glycoprotein epitopes. It has long been known that dysregulated synthesis of O-linked (threonine or serine) sugars occurs in many cancers,...
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