Article
Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease.
Blood - 1 Oct 2007
Savoldo Barbara, Rooney Cliona M, Di Stasi Antonio, Abken Hinrich, Hombach Andreas, Foster Aaron E, Zhang Lan, Heslop Helen E, Brenner Malcolm K, Dotti Gianpietro
Abstract excerpt
Adoptive transfer of Epstein Barr virus (EBV)-specific cytotoxic T-lymphocytes (EBV-CTLs) has shown that these cells persist in patients with EBV(+) Hodgkin lymphoma (HD) to produce complete tumor responses. Treatment failure, however, occurs if a subpopulation of malignant cells in the tumor lacks or loses expression of EBV antigens. We have therefore determined whether we could prepare EBV-CTLs that retained...
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