Article
Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2011
Joyce M Gordon, Tran Paul, Zhuravleva Marina A, Jaw Jessica, Colonna Marco, Sun Peter D
Abstract excerpt
Natural killer (NK) cells are a group of innate immune cells that carry out continuous surveillance for the presence of virally infected or cancerous cells. The natural cytotoxicity receptor (NCR) NKp30 is critical for the elimination of a large group of tumor cell types. Although several ligands have been proposed for NKp30, the lack of a conserved structural feature among these ligands and their uncertain...
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