Article
Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6.
Protein engineering, design & selection : PEDS - 1 Oct 2017
Hua Casey K, Gacerez Albert T, Sentman Charles L, Ackerman Margaret E
Abstract excerpt
As a stress-inducible natural killer (NK) cell ligand, B7H6 plays a role in innate tumor immunosurveillance and is a fairly tumor selective marker expressed on a variety of solid and hematologic cancer cells. Here, we describe the isolation and characterization of a new family of single chain fragment variable (scFv) molecules targeting the human B7H6 ligand. Through directed evolution of a yeast surface...
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