Article
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
The Journal of biological chemistry - 7 Sept 2012
Hartmann Jessica, Tran Thuy-Van, Kaudeer Janina, Oberle Karin, Herrmann Julia, Quagliano Isabell, Abel Tobias, Cohnen André, Gatterdam Volker, Jacobs Andrea, Wollscheid Bernd, Tampé Robert, Watzl Carsten, Diefenbach Andreas, Koch Joachim
Abstract excerpt
The natural cytotoxicity receptors are a unique set of activating proteins expressed mainly on the surface of natural killer (NK) cells. The human natural cytotoxicity receptor family comprises the three type I membrane proteins NKp30, NKp44, and NKp46. Especially NKp30 is critical for the cytotoxicity of NK cells against different targets including tumor, virus-infected, and immature dendritic cells. Although...
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