Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients.

doi:10.1126/scitranslmed.aaa2327

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients.

Science translational medicine - 15 Apr 2015

Semeraro Michaela, Rusakiewicz Sylvie, Minard-Colin Véronique, Delahaye Nicolas F, Enot David, Vély Frédéric, Marabelle Aurélien, Papoular Benjamin, Piperoglou Christelle, Ponzoni Mirco, Perri Patrizia, Tchirkov Andrei, Matta Jessica, Lapierre Valérie, Shekarian Tala, Valsesia-Wittmann Sandrine, Commo Frédéric, Prada Nicole, Poirier-Colame Vichnou, Bressac Brigitte, Cotteret Sophie, Brugieres Laurence, Farace Françoise, Chaput Nathalie, Kroemer Guido, Valteau-Couanet Dominique, Zitvogel Laurence

Abstract excerpt

The immunosurveillance mechanisms governing high-risk neuroblastoma (HR-NB), a major pediatric malignancy, have been elusive. We identify a potential role for natural killer (NK) cells, in particular the interaction between the NK receptor NKp30 and its ligand, B7-H6, in the metastatic progression and survival of HR-NB after myeloablative multimodal chemotherapy and stem cell transplantation. NB cells expressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Combined Chemotherapy Protocols

Share to Brain Neoplasms

Share to Disease-Free Survival

Share to Jurkat Cells

Share to Ligands

Share to Neoplasm Metastasis

Share to Neuroblastoma

Source

Open in PubMed

Identifiers

PMID: 25877893
DOI: 10.1126/scitranslmed.aaa2327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients.PMID 25877893Read ↗

B7-H3 in Pediatric Tumors: Far beyond NeuroblastomaSemantic proximity Read ↗

Tumor Microenvironment in Neuroblastoma and Immunotherapeutic Approaches: Towards More Effective TreatmentSemantic proximity Read ↗

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humansSemantic proximity Read ↗

Clinical Relevance of CD4 Cytotoxic T Cells in High-Risk NeuroblastomaSemantic proximity Read ↗

Natural killer cell-based therapies in neuroblastomaSemantic proximity Read ↗

Preferential Expression of B7‐H6 in Glioma Stem‐Like Cells Enhances Tumor Cell Proliferation via the c‐Myc/RNMT AxisSemantic proximity Read ↗

The B7-H3/CD3 immune phenotype identifies prognostic subgroups in neuroblastoma.Semantic proximity Read ↗

KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.Semantic proximity Read ↗

Natural killer/T-cell lymphomas in pediatric and adolescent patients.Semantic proximity Read ↗

Plasma Levels of Soluble HLA-E and HLA-F at Diagnosis May Predict Overall Survival of Neuroblastoma PatientsSemantic proximity Read ↗

Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.Semantic proximity Read ↗

Activated NK cells with a predominance of inhibitory receptors and a decidual-like phenotype expand after autologous HSCT in children with tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.