A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.

doi:10.1038/s41564-021-00911-1

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Article

A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.

Nature microbiology - 1 Jul 2021

Diard Médéric, Bakkeren Erik, Lentsch Verena, Rocker Andrea, Bekele Nahimi Amare, Hoces Daniel, Aslani Selma, Arnoldini Markus, Böhi Flurina, Schumann-Moor Kathrin, Adamcik Jozef, Piccoli Luca, Lanzavecchia Antonio, Stadtmueller Beth M, Donohue Nicholas, van der Woude Marjan W, Hockenberry Alyson, Viollier Patrick H, Falquet Laurent, Wüthrich Daniel, Bonfiglio Ferdinando, Loverdo Claude, Egli Adrian, Zandomeneghi Giorgia, Mezzenga Raffaele, Holst Otto, Meier Beat H, Hardt Wolf-Dietrich, Slack Emma

Abstract excerpt

The ability of gut bacterial pathogens to escape immunity by antigenic variation-particularly via changes to surface-exposed antigens-is a major barrier to immune clearance1. However, not all variants are equally fit in all environments2,3. It should therefore be possible to exploit such immune escape mechanisms to direct an evolutionary trade-off. Here, we demonstrate this phenomenon using Salmonella enterica...

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Identifiers

PMID: 34045711
DOI: 10.1038/s41564-021-00911-1
PMCID: PMC7611113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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