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Article

The intestinal environment potentiates bacteriophage adaptation in response to phenotypic resistance in Salmonella Typhimurium.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2025

Wenner Nicolas, Bertola Anouk, Larsson Louise, Rocker Andrea, Amare Bekele Nahimi, Sauerbeck Chris, Lemos Rocha Leonardo F, Druelle Valentin, Molari Marco, Harms Alexander, Diard Médéric

Abstract excerpt

Heterogeneous gene expression enables the coexistence of virulent phages with populations of isogenic bacteria comprising both phenotypically phage-resistant and susceptible cells. However, the evolvability of phages and the fitness cost they impose on susceptible bacteria challenge the evolutionary stability of the coexistence. Understanding this dynamic is critical for predicting phage-bacteria coevolution with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41055989
DOI: 10.1073/pnas.2507909122
PMCID: PMC12541327

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