Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica.

Infection and immunity - 1 Oct 1999

Igwe E I, Rüssmann H, Roggenkamp A, Noll A, Autenrieth I B, Heesemann J

Abstract excerpt

Three different Yersinia enterocolitica serotype O8 strains harboring mutations in virulence-associated genes coding for Yersinia adhesin A (YadA), Mn-cofactored superoxide dismutase (SodA), and high-molecular-weight protein 1 were analyzed for their ability to colonize and persist in tissues after orogastric immunization of C57BL/6 mice. We demonstrated that all three Yersinia mutant strains were markedly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Antibodies, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacterial Vaccines

Share to Cytokines

Share to Immunization

Share to Interferon-gamma

Share to T-Lymphocytes

Share to Yersinia enterocolitica

Source

Open in PubMed Open full text

Identifiers

PMID: 10496939
DOI: 10.1128/IAI.67.10.5500-5507.1999
PMCID: PMC96914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica.PMID 10496939Read ↗

Attenuated Yersinia enterocolitica mutant strains exhibit differential virulence in cytokine-deficient mice: implications for the development of novel live carrier vaccines.Semantic proximity Read ↗

Live Attenuated S. Typhimurium Vaccine with Improved Safety in Immuno-Compromised MiceSemantic proximity Read ↗

Comparison of the course of infection of virulent Yersinia enterocolitica serotype O:8 with an isogenic sodA mutant in the peroral rabbit model.Semantic proximity Read ↗

IgA response by oral infection with an attenuated Yersinia enterocolitica mutant: implications for its use as oral carrier vaccine.Semantic proximity Read ↗

Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens.Semantic proximity Read ↗

Safety assessment of compliant, highly invasive, lipid A-altered, O-antigen-defected Salmonella strains as prospective vaccine delivery systemsSemantic proximity Read ↗

Construction and evaluation of live attenuated vaccine strains of Shigella flexneri and Shigella dysenteriae 1.Semantic proximity Read ↗

Live-attenuated Salmonella enterica serotype Choleraesuis vaccine with regulated delayed fur mutation confer protection against Streptococcus suis in miceSemantic proximity Read ↗

Contribution of the Mn-cofactored superoxide dismutase (SodA) to the virulence of Yersinia enterocolitica serotype O8.Semantic proximity Read ↗

Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.Semantic proximity Read ↗

Construction of recombinant attenuated Salmonella enterica serovar typhimurium vaccine vector strains for safety in newborn and infant mice.Semantic proximity Read ↗

A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.