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Article

A single nucleotide polymorphism collapses phase variation and drives short-sighted evolution of O-antigen in Salmonella.

Gut microbes - 31 Dec 2026

Cheng Yiluo, Zhang Wenting, Nickerson Rhea, Lu Qin, Guo Yunqing, Hu Qiao, Zhang Rongrong, Wen Guoyuan, Huang Qi, Zhou Rui, Shao Huabin, Cheng Zhenyu, Luo Qingping, Zhang Tengfei

Abstract excerpt

The O-antigen of Salmonella is a key virulence determinant and serotype-defining structure, yet the regulatory mechanisms underlying its dynamic modification and evolutionary trade-offs remain incompletely understood. Salmonella Pullorum is a pathogen that displays both O-antigen unstable phase variation and stable antigenic conversion between standard (O123) and variant (O122) antigenic types. In this study, we...

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Share to Antigenic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Bacterial

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Identifiers

PMID: 42635344
DOI: 10.1080/19490976.2026.2721178
PMCID: PMC13505456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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