Article

Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses

2019-03-16

Abstract excerpt

Genotype imputation has become a standard procedure prior genome-wide association studies (GWASs). For common and low-frequency variants, genotype imputation can be performed sufficiently accurately with publicly available and ethnically heterogeneous reference datasets like 1000 Genomes Project (1000G) and Haplotype Reference Consortium panels. However, the imputation of rare variants has been shown to be signifi...

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Literature Corpus work: f28e5d5c-9b67-5124-b826-31a53397c65d
DOI: 10.1101/579201

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