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Article

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.

Nucleic acids research - 18 Mar 2020

Halmai Julian A N M, Deng Peter, Gonzalez Casiana E, Coggins Nicole B, Cameron David, Carter Jasmine L, Buchanan Fiona K B, Waldo Jennifer J, Lock Samantha R, Anderson Johnathon D, O'Geen Henriette, Segal David J, Nolta Jan, Fink Kyle D

Abstract excerpt

A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here, we created an artificial escape by editing DNA methylation on the promoter of CDKL5, a gene causative for an infantile epilepsy, from the silenced X-chromosomal...

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Share to Chromosomes, Human, X
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Associated Protein 9

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Share to RNA, Guide, CRISPR-Cas Systems

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Source

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Identifiers

PMID: 31925439
DOI: 10.1093/nar/gkz1214
PMCID: PMC7049732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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