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Article

The role of mitochondria in aging.

The Journal of clinical investigation - 1 Mar 2013

Bratic Ana, Larsson Nils-Göran

Abstract excerpt

Over the last decade, accumulating evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the first direct experimental evidence that increased mtDNA mutation levels contribute to progeroid phenotypes came from the mtDNA mutator mouse. Recent...

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Identifiers

PMID: 23454757
DOI: 10.1172/JCI64125
PMCID: PMC3582127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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