Article

Diet induced mitochondrial DNA replication instability in <i>Rad51c</i> mutant mice drives sex-bias in anemia of inflammation

2024-09-21

Abstract excerpt

Anemia of inflammation (AI) is a common comorbidity associated with obesity, diabetes, cardiac disease, aging, and during anti-cancer therapies. Mounting evidence illustrates that males are disproportionally affected by AI, but not why. Here we demonstrate a molecular cause for a sex-bias in inflammation. The data shows that mitochondrial DNA (mtDNA) instability induced by dietary stress causes anemia associated w...

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Literature Corpus work: 22d8c0e9-0347-5f23-b1d3-d09187105371
DOI: 10.1101/2024.09.21.613572

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