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Article

Characterization of non-coding variants associated with transcription-factor binding through ATAC-seq-defined footprint QTLs in liver.

American journal of human genetics - 5 Jun 2025

Dudek Max F, Wenz Brandon M, Brown Christopher D, Voight Benjamin F, Almasy Laura, Grant Struan F A

Abstract excerpt

Non-coding variants discovered by genome-wide association studies (GWASs) are enriched in regulatory elements harboring transcription factor (TF) binding motifs, strongly suggesting a connection between disease association and the disruption of cis-regulatory sequences. Occupancy of a TF inside a region of open chromatin can be detected in ATAC-seq where bound TFs block the transposase Tn5, leaving a pattern of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40250421
DOI: 10.1016/j.ajhg.2025.03.019
PMCID: PMC12256798

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TF

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