Article

Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver

2024-09-25

Abstract excerpt

Non-coding variants discovered by genome-wide association studies (GWAS) are enriched in regulatory elements harboring transcription factor (TF) binding motifs, strongly suggesting a connection between disease association and the disruption of cis-regulatory sequences. Occupancy of a TF inside a region of open chromatin can be detected in ATAC-seq where bound TFs block the transposase Tn5, leaving a pattern of rel...

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Literature Corpus work: c7d06aeb-5fce-5417-8201-059c7b88ca99
DOI: 10.1101/2024.09.24.614730

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