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Article

Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles.

Genomics - 1 Aug 2014

Lo Ken Sin, Vadlamudi Swarooparani, Fogarty Marie P, Mohlke Karen L, Lettre Guillaume

Abstract excerpt

Characterization of the epigenome promises to yield the functional elements buried in the human genome sequence, thus helping to annotate non-coding DNA polymorphisms with regulatory functions. Here, we develop two novel strategies to combine epigenomic data with transcriptomic profiles in humans or mice to prioritize potential candidate SNPs associated with lipid levels by genome-wide association study (GWAS)....

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Identifiers

PMID: 24997396
DOI: 10.1016/j.ygeno.2014.04.006
PMCID: PMC4373602

Genes

FOXA2
SORT1

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