Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals

25 May 2021

Abstract excerpt

Recent advances in high-throughput T cell receptor (TCR) sequencing have allowed for new insights into the human TCR repertoire. However, methods for capturing antigen-specific repertoires remain an area of development. Here, we describe a potentially novel approach that utilizes both a biological and statistical enrichment to define putatively antigen-specific complementarity-determining region 3 (CDR3)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergic Rhinitis and Sensitization
Share to Asthma and respiratory diseases
Share to Food Allergy and Anaphylaxis Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34032640
DOI: 10.1172/jci.insight.140028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individualsPMID 34032640Read ↗

Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequencesSemantic proximity Read ↗

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing.Semantic proximity Read ↗

Systematic comparative study of computational methods for T-cell receptor sequencing data analysisSemantic proximity Read ↗

T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.Semantic proximity Read ↗

Tools for fundamental analysis functions of TCR repertoires: a systematic comparisonSemantic proximity Read ↗

Characterization of the diversity of T cell receptor γδ complementary determinant region 3 in human peripheral blood by Immune Repertoire Sequencing.Semantic proximity Read ↗

TCRosetta: a powerful server for analyzing and annotating T-cell receptor repertoireSemantic proximity Read ↗

Discovery of rare antigen-specific TCRs via replicate profilingSemantic proximity Read ↗

A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping.Semantic proximity Read ↗

Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and miceSemantic proximity Read ↗

High Throughput Sequencing of T Cell Antigen Receptors Reveals a Conserved TCR Repertoire.Semantic proximity Read ↗

Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence RepertoiresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.