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Article

Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation.

Nature immunology - 1 Jul 2021

Chen Dianyu, Wang Yan, Manakkat Vijay Godhev K, Fu Shujie, Nash Colt W, Xu Di, He Danyang, Salomonis Nathan, Singh Harinder, Xu Heping

Abstract excerpt

Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive selection of GC B cells that acquire high-affinity mutations enables antibody affinity maturation. In spite of considerable progress, the genomic states underlying this process remain to be elucidated. Single-cell RNA sequencing and topic modeling revealed increased...

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Share to Alkyl and Aryl Transferases
Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34031613
DOI: 10.1038/s41590-021-00936-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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