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Article

Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis.

Nature medicine - 1 Jul 2021

Gygli Sebastian M, Loiseau Chloé, Jugheli Levan, Adamia Natia, Trauner Andrej, Reinhard Miriam, Ross Amanda, Borrell Sonia, Aspindzelashvili Rusudan, Maghradze Nino, Reither Klaus, Beisel Christian, Tukvadze Nestani, Avaliani Zaza, Gagneux Sebastien

Abstract excerpt

Multidrug-resistant tuberculosis (MDR-TB) accounts for one third of the annual deaths due to antimicrobial resistance1. Drug resistance-conferring mutations frequently cause fitness costs in bacteria2-5. Experimental work indicates that these drug resistance-related fitness costs might be mitigated by compensatory mutations6-10. However, the clinical relevance of compensatory evolution remains poorly understood....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34031604
DOI: 10.1038/s41591-021-01358-x
PMCID: PMC9400913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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