Article
Compensation of fitness costs and reversibility of antibiotic resistance mutations.
Antimicrobial agents and chemotherapy - 1 May 2010
Schulz zur Wiesch Pia, Engelstädter Jan, Bonhoeffer Sebastian
Abstract excerpt
Strains of bacterial pathogens that have acquired mutations conferring antibiotic resistance often have a lower growth rate and are less invasive or transmissible initially than their susceptible counterparts. However, fitness costs of resistance mutations can be ameliorated by secondary site mutations. These so-called compensatory mutations may restore fitness in the absence and/or presence of antimicrobials. We...
Topics
- Adaptation, Physiological
- Anti-Bacterial Agents
- Bacteria
- Biological Evolution
- Drug Resistance, Bacterial
- Extinction, Biological
- Genotype
- Models, Genetic
- Mutation