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MTHFR C677T and A1298C variants in Mexican Mestizo infants with neural tube defects from Western Mexico.

Congenital anomalies - 1 Sept 2021

Aranda-Sánchez Cristian Irela, Bobadilla-Morales Lucina, Corona-Rivera Alfredo, Cuero-Quezada Idalid, Santana-Hernández Jennifer, Baldomero-López Alejandra, Romero-Bolaño Yaneris M, Peña-Padilla Christian, Corona-Rivera Jorge Román

Abstract excerpt

Our study investigated the role of MTHFR C677T and A1298C variants in infants with neural tube defects (NTDs) from western Mexico. Using TaqMan allelic discrimination assay, we genotyped 101 live-born patients with NTDs (cases) and 247 controls. Our findings do not support that homozygosity or heterozygosity for the variants C677T and A1298C in the MTHFR gene are associated with NTDs in infants. However, since we...

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PMID: 34015145
DOI: 10.1111/cga.12429

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