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Article

Heterogenous Distribution of MTHFR Gene Variants among Mestizos and Diverse Amerindian Groups from Mexico.

PloS one - 1 Jan 2016

Contreras-Cubas Cecilia, Sánchez-Hernández Beatríz E, García-Ortiz Humberto, Martínez-Hernández Angélica, Barajas-Olmos Francisco, Cid Miguel, Mendoza-Caamal Elvia C, Centeno-Cruz Federico, Ortiz-Cruz Gabriela, Jiménez-López José Concepción, Córdova Emilio J, Salas-Bautista Eva Gabriela, Saldaña-Alvarez Yolanda, Fernández-López Juan Carlos, Mutchinick Osvaldo M, Orozco Lorena

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folate deficiency has been related to several conditions, including neural tube defects (NTDs) and cardiovascular diseases. Hence, MTHFR genetic variants have been studied worldwide, particularly the C677T and A1298C. We genotyped the C677T and A1298C MTHFR polymorphisms in Mexican Amerindians (MAs), from the largest sample included...

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PMID: 27649570
DOI: 10.1371/journal.pone.0163248
PMCID: PMC5029802

Genes

MTHFR

Variants

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