<em>NRAS</em>-mutant melanoma: current challenges and future prospect

Abstract excerpt

Abstract: Melanoma is one of the most common cutaneous cancers worldwide. Activating mutations in RAS oncogenes are found in a third of all human cancers and NRAS mutations are found in 15%–20% of melanomas. The NRAS -mutant subset of melanoma is more aggressive and associated with poorer outcomes, compared to non- NRAS -mutant melanoma. Although immune checkpoint inhibitors and targeted therapies for BRAF...

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