Article
A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.
Scientific reports - 19 Nov 2019
Ticha Ivana, Hojny Jan, Michalkova Romana, Kodet Ondrej, Krkavcova Eva, Hajkova Nikola, Nemejcova Kristyna, Bartu Michaela, Jaksa Radek, Dura Miroslav, Kanwal Madiha, Martinikova Andra S, Macurek Libor, Zemankova Petra, Kleibl Zdenek, Dundr Pavel
Abstract excerpt
The most common histological subtypes of cutaneous melanoma include superficial spreading and nodular melanoma. However, the spectrum of somatic mutations developed in those lesions and all potential druggable targets have not yet been fully elucidated. We present the results of a sequence capture NGS analysis of 114 primary nodular and superficial spreading melanomas identifying driver mutations using...
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