Article
Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations.
Auris, nasus, larynx - 1 Apr 2024
Tsushima Nayuta, Kano Satoshi, Hatanaka Kanako C, Suzuki Takayoshi, Hamada Seijiro, Idogawa Hiroshi, Nakamaru Yuji, Suzuki Masanobu, Hatanaka Yutaka, Homma Akihiro
Abstract excerpt
OBJECTIVE: Mucosal melanoma is a rare malignancy; however, the reported incidence rate of mucosal melanoma is higher in Asians than in Caucasians. Sinonasal mucosal melanoma (SNMM) is an aggressive malignancy with a poor prognosis due to distant metastasis. Systemic therapy with BRAF inhibitor and MEK inhibitor is one of the standards of care for cutaneous melanoma patients with BRAF V600 mutations. However, no...
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