Article
Novel Alzheimer's disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers.
Translational psychiatry - 19 May 2021
Park Jong-Ho, Park Inho, Youm Emilia Moonkyung, Lee Sejoon, Park June-Hee, Lee Jongan, Lee Dong Young, Byun Min Soo, Lee Jun Ho, Yi Dahyun, Chung Sun Ju, Park Kye Won, Choi Nari, Kim Seong Yoon, Yoon Woon, An Hoyoung, Kim Ki Woong, Choi Seong Hye, Jeong Jee Hyang, Kim Eun-Joo, Kang Hyojin, Lee Junehawk, Kim Younghoon, Lee Eunjung Alice, Seo Sang Won, Na Duk L, Kim Jong-Won
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen other genetic loci associated with AD have been identified through genome-wide association studies (GWAS) conducted mainly in individuals of European ancestry. Recently, several GWAS performed in other ethnic groups have shown the importance...
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