Article
Lessons from genome-wide association studies findings in Alzheimer's disease.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society - 1 Mar 2012
Moraes Clayton F, Lins Tulio C, Carmargos Einstein F, Naves Janeth O S, Pereira Rinaldo W, Nóbrega Otávio T
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder with a complex genetic background. Recent genome-wide association studies (GWAS) have placed important new contributors into the genetic framework of early- and late-onset forms of this dementia. Besides confirming the major role of classic allelic variants (e.g. apolipoprotein E) in the development of AD, GWAS have thus far implicated over 20...
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