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Article

Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Fan Kang-Hsien, Feingold Eleanor, Rosenthal Samantha L, Demirci F Yesim, Ganguli Mary, Lopez Oscar L, Kamboh M Ilyas

Abstract excerpt

The genetics of late-onset Alzheimer's disease (AD) is complex due to the heterogeneous nature of the disorder. APOE*4 is the strongest genetic risk factor for AD. Genome-wide association studies have identified more than 30 additional loci, each having relatively small effect size. Known AD loci explain only about 30% of the genetic variance, and thus much of the genetic variance remains unexplained. To identify...

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Identifiers

PMID: 32651314
DOI: 10.3233/JAD-200037
PMCID: PMC7484092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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