Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk.

doi:10.1038/s41398-021-01272-3

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Article

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk.

Translational psychiatry - 3 Mar 2021

Shigemizu Daichi, Mitsumori Risa, Akiyama Shintaro, Miyashita Akinori, Morizono Takashi, Higaki Sayuri, Asanomi Yuya, Hara Norikazu, Tamiya Gen, Kinoshita Kengo, Ikeuchi Takeshi, Niida Shumpei, Ozaki Kouichi

Abstract excerpt

Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow earlier intervention. Genetic risk factors may differ between ethnic populations. To discover novel susceptibility loci of AD in the Japanese population, we conducted a genome-wide association study (GWAS) with 3962 AD cases and 4074 controls. Out of 4,852,957 genetic markers that passed stringent quality control filters,...

Topics

Alzheimer Disease
Case-Control Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Japan
LDL-Receptor Related Proteins
Membrane Transport Proteins
Polymorphism, Single Nucleotide

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Identifiers

PMID: 33654092
DOI: 10.1038/s41398-021-01272-3
PMCID: PMC7925686

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