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Article

Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.

PloS one - 1 Jan 2021

Shirakami Yohei, Nakanishi Takayuki, Ozawa Noritaka, Ideta Takayasu, Kochi Takahiro, Kubota Masaya, Sakai Hiroyasu, Ibuka Takashi, Tanaka Takuji, Shimizu Masahito

Abstract excerpt

Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis in the colorectum. This study aimed to investigate the chemopreventive ability of RQ-15986, a selective EP4 antagonist, in colitis-related colorectal tumorigenesis. Male Kyoto APC delta rats, which have APC mutations, were treated with azoxymethane and dextran sulfate sodium and subsequently administered RQ-15986 for eight weeks....

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Identifiers

PMID: 34003864
DOI: 10.1371/journal.pone.0251942
PMCID: PMC8130959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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