Article
Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.
Cancer science - 1 Jul 2003
Kitamura Tomohiro, Itoh Masaki, Noda Tetsuo, Tani Kousuke, Kobayashi Michiyoshi, Maruyama Takayuki, Kobayashi Kaoru, Ohuchida Shuichi, Sugimura Takashi, Wakabayashi Keiji
Abstract excerpt
Previous studies have shown that prostaglandin E(2) (PGE(2)) is involved in intestinal carcinogenesis through its binding to the PGE(2) receptor subtypes EP(1) and EP(4) and activation of downstream pathways. ONO-8711 and ONO-AE2-227, prostaglandin E receptor subtype EP(1)- and EP(4)-selective antagonists, respectively, are known to suppress formation of intestinal polyps in adenomatous polyposis coli...
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