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Article

Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2008

Khor Tin Oo, Huang Mou-Tuan, Prawan Auemduan, Liu Yue, Hao Xingpei, Yu Siwang, Cheung William Ka Lung, Chan Jefferson Y, Reddy Bandaru S, Yang Chung S, Kong Ah-Ng

Abstract excerpt

The nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a critical role in protecting various tissues against inflammation, which is a potential risk factor for colorectal and other cancers. Our previously published mouse model work showed that Nrf2 helps protect against dextran sulfate sodium (DSS)-induced colitis/inflammation, and others have shown that Nrf2 helps protect against inflammation-associated...

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Identifiers

PMID: 19138955
DOI: 10.1158/1940-6207.CAPR-08-0028
PMCID: PMC3580177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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