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Article

Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2017

Li Dandan, Zhang Youyu, Liu Kun, Zhao Yujie, Xu Beibei, Xu Liang, Tan Li, Tian Yuan, Li Cunxi, Zhang Wenqing, Cao Hanwei, Zhan Yan-Yan, Hu Tianhui

Abstract excerpt

The anti-inflammatory and anti-tumor effects of berberine, a traditional Chinese medicine, were separately discovered in pathological intestinal tissues. However, whether the anti-inflammatory effect of berberine contributes to its anti-tumor effect on colitis-associated colorectal cancer (CACRC) remains unknown. In the present study, we found that berberine effectively inhibited colitis-associated tumorigenesis...

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Identifiers

PMID: 28759012
DOI: 10.1038/labinvest.2017.71

Genes

EGFR
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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