Article

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn’s disease-like murine ileitis via inhibition of inflammatory cytokine expression

2020-01-24

Abstract excerpt

Inhibitors of bromodomain and extra-terminal motif proteins (“BET inhibitors”) are emerging epigenetic therapeutics that exert their effects by suppressing the expression of genes that drive cancer and inflammation. The present study examined the anti-inflammatory effects of a quinazoline-based BET inhibitor, CN210, which also inhibits bromodomains of two paralogous histone acetyltransferases (HATs), such as cAMP-...

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Literature Corpus work: 1deae54b-890d-51aa-b521-df7d6a2e30a9
DOI: 10.1101/2020.01.24.917948

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Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn’s disease-like murine ileitis via inhibition of inflammatory cytokine expressionDOI 10.1101/2020.01.24.917948Read

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