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Article

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.

International journal of cancer - 1 Jul 2018

Ahadova Aysel, Gallon Richard, Gebert Johannes, Ballhausen Alexej, Endris Volker, Kirchner Martina, Stenzinger Albrecht, Burn John, von Knebel Doeberitz Magnus, Bläker Hendrik, Kloor Matthias

Abstract excerpt

Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch syndrome colorectal cancers. Recently, this concept has been challenged by the discovery of MMR-deficient crypt foci in the normal mucosa. We aimed to reconstruct colorectal carcinogenesis in Lynch syndrome by collecting molecular and histology...

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Source

Identifiers

PMID: 29424427
DOI: 10.1002/ijc.31300

Genes

APC
CTNNB1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review)Semantic proximity Read ↗

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