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Article

Mathematical modeling the order of driver gene mutations in colorectal cancer.

PLoS computational biology - 1 Jun 2023

Li Lingling, Hu Yulu, Xu Yunshan, Tang Sanyi

Abstract excerpt

Tumor heterogeneity is a large obstacle for cancer study and treatment. Different cancer patients may involve different combinations of gene mutations or the distinct regulatory pathways for inducing the progression of tumor. Investigating the pathways of gene mutations which can cause the formation of tumor can provide a basis for the personalized treatment of cancer. Studies suggested that KRAS, APC and TP53...

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Identifiers

PMID: 37368936
DOI: 10.1371/journal.pcbi.1011225
PMCID: PMC10332632

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