Article

Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes

2024-04-15

Abstract excerpt

<h4>Background: </h4> Colorectal cancers (CRCs) in the Lynch syndromes have been assumed to emerge through an accelerated adenoma-carcinoma pathway. In this model adenomas with deficient mismatch repair have an increased probability of acquiring additional cancer driver mutation(s) resulting in more rapid progression to malignancy. If this model was accurate, the success of colonoscopy in preventing CRC would be a...

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Literature Corpus work: 45ba0083-eaad-51e9-8950-47dc9cc1f60c
DOI: 10.21203/rs.3.rs-4238470/v1

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