Probability of Antibiotic Resistance During Treatment in Stochastic PK/PD-Based Bacterial Model with Distinct Drug and Mutation Modes.

Abstract excerpt

Mathematical models, e.g., differential equations and stochastic processes, have gained considerable attention for understanding evolution of antibiotic resistance. However, most existing models assume standing genetic variation and do not consider the possibility of random or drug-induced mutation of reference bacterial strains. Therefore, we propose a pharmacokinetics/pharmacodynamics (PK/PD)-based...

Topics

• Stochastic Processes
• Anti-Bacterial Agents
• Mutation
• Drug Resistance, Bacterial
• Models, Biological
• Markov Chains