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Article

Norrbottnian congenital insensitivity to pain.

Acta orthopaedica. Supplementum - 1 Apr 2006

Minde Jan K

Abstract excerpt

Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family. Analysis of candidate genes in the disease-critical region revealed a...

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PMID: 16768023

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