Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Norrbottnian congenital insensitivity to pain.

Acta orthopaedica. Supplementum - 1 Apr 2006

Minde Jan K

Abstract excerpt

Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family. Analysis of candidate genes in the disease-critical region revealed a...

Topics

Female
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
Male
Mutation
Nerve Growth Factors
Pain Insensitivity, Congenital
Pedigree
Prevalence
Risk Assessment
Sweden

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16768023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Norrbottnian congenital insensitivity to pain.PMID 16768023Read ↗

Orthopedic aspects of familial insensitivity to pain due to a novel nerve growth factor beta mutation.Semantic proximity Read ↗

A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perceptionSemantic proximity Read ↗

From genes to pain: nerve growth factor and hereditary sensory and autonomic neuropathy type V.Semantic proximity Read ↗

Familial insensitivity to pain (HSAN V) and a mutation in the NGFB gene. A neurophysiological and pathological study.Semantic proximity Read ↗

Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain.Semantic proximity Read ↗

Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.Semantic proximity Read ↗

Multisystem involvement in congenital insensitivity to pain with anhidrosis (CIPA), a nerve growth factor receptor(Trk A)-related disorder.Semantic proximity Read ↗

Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them.Semantic proximity Read ↗

Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

Orthopedic Challenges in a Pediatric Case of Congenital Insensitivity to Pain with Anhidrosis (Cipa): A Case Report of 3 Years Old Female PatientSemantic proximity Read ↗

Investigation into the molecular mechanisms of congenital insensitivity to painSemantic proximity Read ↗

Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.