Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.

Behavioural brain research - 6 Aug 2021

Partington Heath S, Nutter Jennifer Makenzie, Eells Jeffrey B

Abstract excerpt

Neurological and neuropsychiatric disorders, including addiction, schizophrenia, and Parkinson's disease (PD), involve dysfunction in midbrain dopamine (DA) neurotransmission with severity of disease symptoms and progression associated with disrupted circadian rhythms. The nuclear transcription factor Nurr1, essential for DA neuron (DAN) development, survival, and maintenance, is also known to interact with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Gene Expression

Share to Heterozygote

Share to Mice, Inbred C57BL

Share to Nuclear Receptor Subfamily 4, Group A, Member 2

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 33991560
DOI: 10.1016/j.bbr.2021.113347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nurr1 deficiency shortens free running period, enhances photoentrainment to phase advance, and disrupts circadian cycling of the dopamine neuron phenotype.PMID 33991560Read ↗

NURR1-deficient mice have age- and sex-specific behavioral phenotypes.Semantic proximity Read ↗

Circadian Modulation of Dopamine Levels and Dopaminergic Neuron Development Contributes to Attention Deficiency and Hyperactive BehaviorSemantic proximity Read ↗

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene.Semantic proximity Read ↗

The control of dopamine neuron development, function and survival: insights from transgenic mice and the relevance to human disease.Semantic proximity Read ↗

RCAN1 Knockout and Overexpression Recapitulate an Ensemble of Rest-activity and Circadian Disruptions Characteristic of Down Syndrome, Alzheimer’s Disease, and Normative AgingSemantic proximity Read ↗

Quantitative differences in the circadian rhythm of locomotor activity and vasopressin and vasoactive intestinal peptide gene expression in the suprachiasmatic nucleus of tau mutant compared to wildtype hamsters.Semantic proximity Read ↗

Constant light uncovers behavioral effects of a mutation in the schizophrenia risk gene Dtnbp1 in mice.Semantic proximity Read ↗

Nitric Oxide Mediates Neuro-Glial Interaction that Shapes <i>Drosophila</i> Circadian BehaviorSemantic proximity Read ↗

Pgc-1α and Nr4a1 Are Target Genes of Circadian Melatonin and Dopamine Release in Murine Retina.Semantic proximity Read ↗

Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.Semantic proximity Read ↗

Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra.Semantic proximity Read ↗

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.