Article
Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice.
The EMBO journal - 15 Jul 1998
André E, Conquet F, Steinmayr M, Stratton S C, Porciatti V, Becker-André M
Abstract excerpt
The orphan nuclear receptor RORbeta is expressed in areas of the central nervous system which are involved in the processing of sensory information, including spinal cord, thalamus and sensory cerebellar cortices. Additionally, RORbeta localizes to the three principal anatomical components of the...
Topics
- Animals
- Ataxia
- Behavior, Animal
- Central Nervous System
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Circadian Rhythm
- Evoked Potentials, Visual
- Humans
- Infertility, Male
- Male
- Mice
- Mice, Transgenic
- Phenotype
- Pineal Gland
- RNA, Messenger
- Rats
- Rats, Sprague-Dawley