Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models.

The Journal of biological chemistry - 1 Jan 2000

Konovalov Kirill A, Wang Wei, Wang Guo, Goonetilleke Eshani C, Gao Xin, Wang Dong, Huang Xuhui

Abstract excerpt

RNA polymerase II (Pol II) surveils the genome, pausing as it encounters DNA lesions and base modifications and initiating signals for DNA repair among other important regulatory events. Recent work suggests that Pol II pauses at 5-carboxycytosine (5caC), an epigenetic modification of cytosine, because of a specific hydrogen bond between the carboxyl group of 5caC and a specific residue in fork loop 3 of Pol II....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosine
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Markov Chains

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcription, Genetic

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 33991521
DOI: 10.1016/j.jbc.2021.100735
PMCID: PMC8191312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models.PMID 33991521Read ↗

DNA lesion bypass and the stochastic dynamics of transcription-coupled repair.Semantic proximity Read ↗

Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II.Semantic proximity Read ↗

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5Semantic proximity Read ↗

Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.Semantic proximity Read ↗

A sequence-encoded promoter proximal super pause stabilizes an offline RNA polymerase II stateSemantic proximity Read ↗

Nucleic acid sequence determinants of transcriptional pausing by human mitochondrial RNA polymerase (POLRMT)Semantic proximity Read ↗

Investigating the structural changes due to adenosine methylation of the Kaposi’s sarcoma-associated herpes virus ORF50 transcriptSemantic proximity Read ↗

Mechanism of T7 RNAP pausing and termination at the T7 concatemer junction: a local change in transcription bubble structure drives a large change in transcription complex architecture.Semantic proximity Read ↗

Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.Semantic proximity Read ↗

A ratchet mechanism of transcription elongation and its control.Semantic proximity Read ↗

Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.Semantic proximity Read ↗

A bridge to transcription by RNA polymerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.