Article
Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.
Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2014
Xu Liang, Zhang Lu, Chong Jenny, Xu Jun, Huang Xuhui, Wang Dong
Abstract excerpt
Nonenzymatic RNA polymerization in early life is likely to introduce backbone heterogeneity with a mixture of 2'-5' and 3'-5' linkages. On the other hand, modern nucleic acids are dominantly composed of 3'-5' linkages. RNA polymerase II (pol II) is a key modern enzyme responsible for synthesizing 3'-5'-linked RNA with high fidelity. It is not clear how modern enzymes, such as pol II, selectively recognize 3'-5'...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.