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Article

Decoding Cancer-Associated Mutations in DNA Polymerase η through Atomistic Simulations.

Journal of chemical theory and computation - 25 Aug 2026

Visigalli Alessia, Carloni Paolo, De Vivo Marco

Abstract excerpt

DNA polymerases (Pols) are essential enzymes for DNA replication within the cell. However, DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) induced by ultraviolet (UV) radiation, can impair Pols's function and DNA replication. Therefore, the presence of CPDs can, for example, lead to xeroderma pigmentosum variant (XP-V), a rare genetic disorder characterized by an increased risk of skin cancer....

Read the complete abstract on PubMed

Topics

DNA-Directed DNA Polymerase
Humans
Y-Family DNA Polymerases
Mutation
Molecular Dynamics Simulation
Translesion DNA Synthesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA

Pyrimidine Dimers

Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42166703
DOI: 10.1021/acs.jctc.6c00345
PMCID: PMC13523637

Genes

CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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