Article

Macrophage Function is Regulated by NPM1-mediated 2’-O-methylation

2020-04-18

Abstract excerpt

The NPM1 gene is frequently a target of genetic alteration in hematological tumors, particularly of the myeloid lineage. Complete inactivation of Npm1 in the mouse disrupts primitive hematopoiesis and results in embryonic lethality. Npm1 heterozygosity produces features similar to those of MDS that progress to overt leukemia, and specific point mutations of Npm1 lead to bone marrow failure due to loss of hemat...

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Literature Corpus work: a7fe9ab0-12a2-5d8d-bbbf-e67f89a27b35
DOI: 10.1101/2020.04.18.048223

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