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Mutant huntingtin in the extracellular matrix: A new perspective on Huntington's disease pathology.

Neurobiology of disease - 1 Sept 2026

Trabolsi Christine, Cicchetti Francesca

Abstract excerpt

Huntington's disease (HD) is a monogenic neurodegenerative disorder characterized by extensive brain pathology. While its underlying cause has been attributed to intracellular mutant huntingtin (mHTT), growing evidence reveals that mHTT is also present, and biologically active, outside cells. Detected in cerebrospinal fluid, plasma, and brain tissue, extracellular mHTT can induce toxicity and spread between...

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PMID: 42361862
DOI: 10.1016/j.nbd.2026.107502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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